ANTIGENS PRE-BOUND TO THE PRIMATE ERYTHROCYTE COMPLEMENT RECEPTOR VIACROSS-LINKED BISPECIFIC MONOCLONAL-ANTIBODY HETEROPOLYMERS ARE RAPIDLY CLEARED FROM THE CIRCULATION

We have used cross-linked, bispecific monoclonal antibody heteropolyme rs, specific for primate erythrocyte (E) complement receptor (CR1) and target antigen (Ag), to attach I-125-labeled Ag to Cr-51-labeled monk ey erythrocytes (E) in vitro. Injection of these sensitized E into mon keys leads to rapid clearance from the circulation of several differen t I-125-labeled Ag with little, if any sequestration, lysis, or cleara nce of the E. It should now be possible, in principle, to use the hete ropolymer-E system to facilitate the clearance of blood-borne pathogen s from the circulation.