NEW DEVELOPMENTS IN MICROSCALE SEPARATIONS AND MASS-SPECTROMETRY FOR BIOMONITORING - CAPILLARY ELECTROPHORESIS AND ELECTROSPRAY-IONIZATION MASS-SPECTROMETRY

In this article, we briefly highlight the use of capillary electrophor esis for sampling, manipulating, and separating extremely small sample sizes. The extraordinary sensitivity that can be obtained by combined capillary electrophoresis-mass spectrometry is then demonstrated usin g recent results. We briefly describe the ability to detect noncovalen tly associated complexes (e.g., double-stranded DNA) by electrospray i onization-mass spectrometry, and conclude with recent results that sho w the potential for using high-resolution Fourier transform ion cyclot ron resonance (FT-ICR) mass spectrometry for characterization of biomo lecules.