K. Matsuura et al., FUNGAL METABOLITES .9. SYNTHESIS OF A MEMBRANE-MODIFYING PEPTIDE, HYPELCIN A-III, FROM HYPOCREA-PELTATA, Chemical and Pharmaceutical Bulletin, 41(11), 1993, pp. 1955-1959
A membrane-modifying peptide antibiotic having uncoupling activity on
rat liver mitochondria, hypelcin A-III, has been synthesized by assemb
ling five peptide fragments via the N,N'-dicyclohexylcarbodiimide meth
od. The synthesized hypelcin A-III was identical with the natural prod
uct.