SYNTHESIS AND MITOGENIC ACTIVITY OF CHIRAL LIPOPEPTIDE WS1279 AND ITSDERIVATIVES

Authors
KURIMURA M OCHIAI A ACHIWA K
Citation
M. Kurimura et al., SYNTHESIS AND MITOGENIC ACTIVITY OF CHIRAL LIPOPEPTIDE WS1279 AND ITSDERIVATIVES, Chemical and Pharmaceutical Bulletin, 41(11), 1993, pp. 1965-1970
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
41
Issue
11
Year of publication
1993
Pages
1965 - 1970
Database
ISI
SICI code
0009-2363(1993)41:11<1965:SAMAOC>2.0.ZU;2-Y
Abstract
Optically active lipopeptide derivatives have been synthesized by the use of chiral glycerol derivatives. Lipopeptide WS1279 derivatives wit h (R)-glycerol moieties showed a higher mitogenic activity than those with the (S)-configuration. Various N-protected lipopeptide and N-depr otected derivatives showed increased mitogenic activity.