THE LIPOPHOSPHOGLYCAN OF LEISHMANIA AND MACROPHAGE PROTEIN-KINASE-C

Authors
DESCOTEAUX A TURCO SJ
Citation
A. Descoteaux et Sj. Turco, THE LIPOPHOSPHOGLYCAN OF LEISHMANIA AND MACROPHAGE PROTEIN-KINASE-C, Parasitology today, 9(12), 1993, pp. 468-471
Citations number
38
Categorie Soggetti
Parasitiology
Journal title
Parasitology today → ACNP
ISSN journal
01694758
Volume
9
Issue
12
Year of publication
1993
Pages
468 - 471
Database
ISI
SICI code
0169-4758(1993)9:12<468:TLOLAM>2.0.ZU;2-T
Abstract
Lipophosphoglycan (LPG), the major cell-surface glycoconjugate of Leis hmania promastigotes, is an essential virulence determinant. One featu re of LPG resides in its strong inhibitory effect on the activity of p urified protein kinase C (PKC). In this article, Albert Descoteaux and Salvatore Turco briefly review the evidence that LPG effectively inhi bits PKC activity in the macrophage, and discuss the implication of su ch inhibition on Leishmania intramacrophage survival.