INTERFERENCE OF METAMIZOL (DIPYRONE) ON THE DETERMINATION OF CREATININE WITH THE KODAK DRY CHEMISTRY SLIDE COMPARISON WITH THE ENZYMATIC METHOD FROM BOEHRINGER
Ma. Bagnoud et Jp. Reymond, INTERFERENCE OF METAMIZOL (DIPYRONE) ON THE DETERMINATION OF CREATININE WITH THE KODAK DRY CHEMISTRY SLIDE COMPARISON WITH THE ENZYMATIC METHOD FROM BOEHRINGER, European journal of clinical chemistry and clinical biochemistry, 31(11), 1993, pp. 753-757
In order to eliminate positive interferences that take place with the
Jaffe technique, the Kodak Ektachem and Boehringer Mannheim Companies
have chosen an enzymatic method for the determination of creatinine in
serum and urine. Pathological and clinical samples often contain meta
bolites in elevated concentrations or exogenous compounds such as drug
s or toxic compounds. We noticed that patients receiving metamizol-con
taining drugs showed unusually low values of creatinine when determine
d with an Ektachem analyser. We investigated the effect of the main me
tabolites of this prodrug on the creatinine enzymatic methods of Kodak
and Boehringer. We concluded that methyl-amino-antipyrine, the active
substance after administration of metamizol (prop. INN) was responsib
le for the interference, and that no reliable determination of creatin
ine could be performed with these methods in the serum of patients rec
eiving this drug.