SUMATRIPTAN DOES NOT AFFECT VASOPRESSIN SECRETION IN HUMANS

Authors
BARRECA T FRANCESCHINI R CATALDI A CIANCIOSI P ROLANDI E GARIBALDI A
Citation
T. Barreca et al., SUMATRIPTAN DOES NOT AFFECT VASOPRESSIN SECRETION IN HUMANS, Clinical neuropharmacology, 16(6), 1993, pp. 555-558
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy",Neurosciences
Journal title
Clinical neuropharmacology → ACNP
ISSN journal
03625664
Volume
16
Issue
6
Year of publication
1993
Pages
555 - 558
Database
ISI
SICI code
0362-5664(1993)16:6<555:SDNAVS>2.0.ZU;2-D
Abstract
The aim of the study was to investigate the effects of a new seretonin ergic drug, sumatriptan, on arginine vasopressin secretion in humans. Plasma vasopressin concentrations were determined in eight healthy vol unteers, before and after administration of 6 mg of sumatriptan, or pl acebo. No changes in hormone levels were found after sumatriptan or pl acebo administration. The results suggest that in humans serotoninergi c mechanisms, which modulate vasopressin secretion, do not involve the serotonin receptor activated by sumatriptan.