Recurrent episodes of sudden unexplained syncope are a common complain
t of patients referred to health care professionals for evaluation. Tr
aditional evaluations are both time consuming and expensive and leave
many patients without a diagnosis. Although vasovagally mediated episo
des of hypotension and bradycardia have been thought to be a common ca
use of unexplained syncope, this was traditionally a diagnosis of excl
usion. Head-upright tilt table testing has recently emerged as a valua
ble method for confirming the diagnosis of vasovagal syncope and has a
llowed a better understanding of this phenomena. This article reviews
the pathophysiology of vasovagal syncope. the use of head-upright tilt
table testing in its diagnosis, and potential therapies used to preve
nt recurrences.