V. Fraser et al., RESULTS OF A RUBELLA SCREENING-PROGRAM FOR HOSPITAL EMPLOYEES - A 5-YEAR REVIEW (1986-1990), American journal of epidemiology, 138(9), 1993, pp. 756-764
The Barnes Hospital Employee Health Service (St. Louis, Missouri) rube
lla screening program was evaluated over the 5-year period between Jan
uary 1, 1986, and December 31, 1990. A total of 6,969 new employees we
re hired, and 6,115 (87.7%) were screened for evidence of rubella immu
nity by the Employee Health Service. Rubella serology was performed on
5,893 (96.4%) of the screened employees, while 222 (3.6%) had documen
tation of prior rubella vaccination or rubella infection. The absence
of immunity was identified in 325 employees or 5.3% of all those scree
ned. Women were more frequently screened by the Employee Health Servic
e than were men (p < 0.0001), and blacks were more frequently screened
than were non-Hispanic Caucasians (p < 0.0001). Physicians were less
frequently screened than were other departmental groups (p < 0.0001).
The rate of seronegativity for each year of hire varied from 4.45 to 6
.76%, but these differences were not significant. Logistic regression
analysis demonstrated that 5-year birth cohorts correlated significant
ly with serologic status. Employees born in 1960-1964 were least likel
y to be seronegative, and employees born in 1970 or later were most li
kely to be seronegative. Sex, race, and department group were not pred
ictive of serologic status, although significant differences in result
s from different rubella assays were detected. Only 13.8% of seronegat
ive employees were subsequently vaccinated by the Employee Health Serv
ice. This study demonstrates a lower seronegativity rate than did prev
ious studies. It identifies groups of employees likely to escape rubel
la screening and low vaccination rates. It finds increasing seronegati
vity among employees born after 1964 that correlates with the reported
increasing rates of rubella in the United States.