THE RELATIONSHIP BETWEEN THE DEGRADATION OF PROSTACYCLIN IN BLOOD ANDANTIPLATELET DRUG EFFECTS IN PATIENTS WITH ATHEROSCLEROSIS

Citation
Se. Akopov et Es. Gabrielian, THE RELATIONSHIP BETWEEN THE DEGRADATION OF PROSTACYCLIN IN BLOOD ANDANTIPLATELET DRUG EFFECTS IN PATIENTS WITH ATHEROSCLEROSIS, Journal of clinical pharmacology, 33(11), 1993, pp. 1048-1051
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy
ISSN journal
00912700
Volume
33
Issue
11
Year of publication
1993
Pages
1048 - 1051
Database
ISI
SICI code
0091-2700(1993)33:11<1048:TRBTDO>2.0.ZU;2-U
Abstract
Blood and plasma from 109 patients with atherosclerosis and 70 healthy volunteers were tested to study the rate of prostacyclin (PGI2) hydro lysis. It has been reported that patients with atherosclerosis have th e enhanced velocity of PGI2 degradation. The increase in the velocity was more marked in blood than in plasma. The significant negative corr elation between antiaggregation effects of pentoxifylline, nifedipine, and dipyridamole and the velocity of PGI2 degradation in the patients was found. These data suggest that the increase of PGI2 biosynthesis by the drugs studied can enhance their antiaggregation effect if proce sses of PGI2 degradation in blood are not accelerated.