IMMUNOPHILIN RECEPTORS FOR IMMUNOSUPPRESSIVE DRUGS

Authors
SOLDIN SJ MURTHY JN DONNELLY JG CHEN Y GOODYEAR N
Citation
Sj. Soldin et al., IMMUNOPHILIN RECEPTORS FOR IMMUNOSUPPRESSIVE DRUGS, Therapeutic drug monitoring, 15(6), 1993, pp. 468-471
Citations number
30
Categorie Soggetti
Pharmacology & Pharmacy","Public, Environmental & Occupation Heath",Toxicology,Biology
Journal title
Therapeutic drug monitoring → ACNP
ISSN journal
01634356
Volume
15
Issue
6
Year of publication
1993
Pages
468 - 471
Database
ISI
SICI code
0163-4356(1993)15:6<468:IRFID>2.0.ZU;2-Z
Abstract
The major immunophilins that bind cyclosporine (cyclophilin) and FK-50 6/rapamycin (FK-BP 12) have been well characterized. They possess rota mase activity, which is inhibited by the immunosuppressant that binds to them. The immunosuppressive action does not appear to be coupled to rotamase activity. The literature is reviewed on some possible mechan isms of immunosuppression. Minor immunophilins of 14, 36, and 52 kDa h ave also been isolated and partially characterized. Receptor assays em ploying immunophilins have been developed.