BUCCAL MUCOSA BLEEDING-TIME IS PROLONGED IN CANINE MODELS OF PRIMARY HEMOSTATIC DISORDERS

Bleeding times are reported in many studies using canine models, with a variety of techniques employed to adapt these tests for dogs. We eva luated a canine model of template bleeding time, the buccal mucosa ble eding time (BMBT), by examining the test's sensitivity and specificity for defects of primary hemostasis. We examined thirty-five dogs havin g defined defects of either primary hemostasis (Types I, II, III von W illebrand's disease, thrombasthenia, thrombopathia) or secondary hemos tasis (hemophilia A and B, Factor VII deficiency). Comparisons of BMBT and cuticle bleeding time were made in a subset of these dogs. All do gs having primary hemostatic disorders had long BMBT, and all factor d eficient dogs had BMBT within normal range. The BMBT in canine models appears to be a specific and sensitive test of primary hemostasis; sui table for evaluating factors affecting template bleeding time and pote ntial efficacy and thrombogenicity of treatment regimens.