This review outlines many of the recent advancements in the understand
ing and management of the anophthalmic patient. A population-based stu
dy demonstrated that the annual incidence of enucleations for all caus
es was about 3 to 5 per 100,000. Application of expandable orbital imp
lants appears to be promising in the management of microphthalmia or a
nophthalmia in infants to maximize orbital growth. Some reports on the
use of hydroxyapatite enucleation implants are encouraging, with no m
ajor complications observed in one large series. Yet other reports of
hydroxyapatite implant exposures, at a very concerning frequency, are
also beginning to emerge. Few of the exposures heal spontaneously; how
ever, infections or extrusions are very rare, and they are attributabl
e to the porous composition of the implant. Conjunctival flaps alone a
re suboptimal in the management of exposures. Adjunctive autologous fa
scial grafts seem preferable to heterologous sclera in the management
of these exposures. Magnetic resonance imaging of the hydroxyapatite i
mplant appears to be superior to bone scan in the noninvasive assessme
nt of vascularization of these implants. Further advancements are nece
ssary to achieve a more optimal enucleation implant.