CHRONIC NICOTINE INTAKE CAUSES VASCULAR DYSREGULATION IN THE RAT GASTRIC-MUCOSA

Citation
M. Battistel et al., CHRONIC NICOTINE INTAKE CAUSES VASCULAR DYSREGULATION IN THE RAT GASTRIC-MUCOSA, Gut, 34(12), 1993, pp. 1688-1692
Citations number
29
Categorie Soggetti
Gastroenterology & Hepatology
Journal title
GutACNP
ISSN journal
00175749
Volume
34
Issue
12
Year of publication
1993
Pages
1688 - 1692
Database
ISI
SICI code
0017-5749(1993)34:12<1688:CNICVD>2.0.ZU;2-J
Abstract
Chronic cigarette smoking has adverse effects on peptic ulcer disease because the healing of ulcers is delayed and the incidence of relapses is enhanced. Short term intake of nicotine induces vascular damage in the rat gastric mucosa, but the pathophysiological mechanisms of nico tine's action in the stomach are largely unknown. In this study rats w ere treated with nicotine, added to their drinking water, for 50 days. They were then anaesthetised and their stomachs perfused with acidifi ed acetylsalicylic acid (ASA). Chronic nicotine treatment failed to ch ange the effects of acidified ASA to induce gastric mucosal acid back diffusion, haemorrhagic damage and bleeding. Basal blood flow in the g astric mucosa was also unchanged by chronic nicotine intake, whereas t he mucosal hyperaemia evoked by ASA induced acid back diffusion was av erted. The concentrations of sulfidoleukotrienes were significantly au gmented in the gastric wall of nicotine treated rats. These data show that chronic nicotine intake causes dysregulation of the gastric micro circulation, an effect that is associated with biochemical changes in the stomach. This study thus substantiates the adverse effects of smok ing on gastric mucosal pathophysiology. These data suggest that inappr opriate regulation of gastric mucosal blood flow inhibits recovery fro m gastric mucosal injury in smokers.