INTERACTION OF CLAVULANATE WITH CLASS-C BETA-LACTAMASES

Authors
MONNAIE D FRERE JM
Citation
D. Monnaie et Jm. Frere, INTERACTION OF CLAVULANATE WITH CLASS-C BETA-LACTAMASES, FEBS letters, 334(3), 1993, pp. 269-271
Citations number
9
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
334
Issue
3
Year of publication
1993
Pages
269 - 271
Database
ISI
SICI code
0014-5793(1993)334:3<269:IOCWCB>2.0.ZU;2-G
Abstract
The interactions between clavulanate and three class C enzymes have be en studied in detail. In all cases, the reactions followed branched pa thways where 25-150 turnovers occurred before inactivation was complet ed. Reactivation rates were quite low. The poor efficiency of clavulan ate as a class C inactivator appeared to rest upon a very slow acylati on of the protein, and of a relatively high turnover rate.