QUERCETIN POTENTIATES TNF-INDUCED ANTIVIRAL ACTIVITY

Tumor necrosis factor (TNF) produces a dose-dependent inhibition of ve sicular stomatitis virus (VSV), encephalomyocarditis virus (EMCV), and herpes simplex virus type 1 (HSV-1) replication in WISH cells. The an tiviral activity of TNF against VSV and EMCV is greatly enhanced by co mbination with quercetin. Induction of 2',5'-oligo-adenylate (2-5A) sy nthetase by TNF is also enhanced by quercetin. Addition of polyclonal antibodies to human interferon (IFN)-beta completely blocked both enha ncement of antiviral activity and 2-5A synthetase induction.