P. Sjogren et al., MYOCLONIC SPASMS DURING TREATMENT WITH HIGH-DOSES OF INTRAVENOUS MORPHINE IN RENAL-FAILURE, Acta anaesthesiologica Scandinavica, 37(8), 1993, pp. 780-782
Myoclonic spasms occurred in a patient suffering from renal failure af
ter high doses of continuous intravenous morphine (100 mg/h). The conc
entrations of morphine, morphine-6-glucuronide and morphine-3-glucoron
ide (mumol/l) in plasma were: 1.93, 52.06 and 381.8, and in cerebrospi
nal fluid were: 1.02, 5.86 and 61.82, respectively. The role of morphi
ne and morphine glucuronides in myoclonic spasms is discussed.