PASSIVE TRANSFER OF IGE-MEDIATED CUTANEOUS REACTIVITY IN HETEROLOGOUSSPECIES

The transfer of cutaneous hypersensitivity was performed in humans, mo nkeys, and dogs, using the Prausnitz-Kustner (PK) reaction. Quantitati ve end point titrations were used to study reactions resulting from se ra from allergic humans, monkeys, and canines. IgE antibody from dogs sensitized human and rhesus monkey skin. IgE antibody from humans and rhesus monkeys did not sensitize canine skin. The Fc receptors on prim ate mast cells must have broader stoichiometric adaptation for IgE Fc receptors than the analogous Fc receptors on canine mast cells.