DISRUPTION OF THE IMMUNOPEPTIDERGIC NETWORK IN DIETARY MIGRAINE

This investigation is devoted to the study of the time-course of a cyt okines panel (IL-4, IL-6, IFN-gamma, GM-CSF) in plasma samples from mi graine patients. The data obtained during challenged migraine crises w as compared to the baseline values. Time-data series analysis showed a fall after a challenge test for IL-4 and IL-6 plasma levels and an op posite trend for gamma-IFN and GM-CSF levels. The implication of this phenomenon in dietary migraine is not readily evident. There may possi bly be an activation of this cytokine network together with the well-k nown impairment in the neuropeptidergic system, considering the close links between interleukins and other cytokines and the neuro-mediators of pain, such as histamine and 5-HT.