POTENTIAL ANTIMALARIALS .18. SOME MONO-MANNICH AND DI-MANNICH BASES OF 3-[7-CHLORO(AND TRIFLUOROMETHYL)QUINOLIN-4-YLAMINO]PHENOL

Authors
BARLIN GB IRELAND SJ NGUYEN TMT KOTECKA B RIECKMANN KH
Citation
Gb. Barlin et al., POTENTIAL ANTIMALARIALS .18. SOME MONO-MANNICH AND DI-MANNICH BASES OF 3-[7-CHLORO(AND TRIFLUOROMETHYL)QUINOLIN-4-YLAMINO]PHENOL, Australian Journal of Chemistry, 46(11), 1993, pp. 1685-1693
Citations number
14
Categorie Soggetti
Chemistry
Journal title
Australian Journal of Chemistry → ACNP
ISSN journal
00049425
Volume
46
Issue
11
Year of publication
1993
Pages
1685 - 1693
Database
ISI
SICI code
0004-9425(1993)46:11<1685:PA.SMA>2.0.ZU;2-9
Abstract
Syntheses are reported for mono- and di-Mannich base derivatives of 3- [7-chloro(and trifluoromethyl)quinolin-4-ylamino]phenols by Mannich re action on 3-[7-chloro(and trifluoromethyl)-quinolin-4-ylamino]phenols or by condensation of Mannich base derivatives of 3-aminophenol, prepa red from 3-nitrophenol, with the appropriate 4-chloroquinoline. The an timalarial activity of in-4'-ylamino)-2,6-bis[pyrrolidin-1''-ylmethyl- (or piperidin-1''-ylmethyl)]phenol against the Fc-27 isolate of Plasmo dium falciparum was comparable to that of chloroquine, and it was not significantly diminished in tests against the chloroquine-resistant K- 1 isolate.