POTENTIAL ANTIMALARIALS .19. SYNTHESES AND TESTING OF )-ALPHA-(7'-TRIFLUOROMETHYLQUINOLIN-4'-YL)METHANOL AND NAPHTHYRIDIN-4-YL)-ALPHA-(PIPERIDIN-2'-YL)METHANOL

Authors
BARLIN GB IRELAND SJ JIRAVINYU C NGUYEN TMT KOTECKA B RIECKMANN KH
Citation
Gb. Barlin et al., POTENTIAL ANTIMALARIALS .19. SYNTHESES AND TESTING OF )-ALPHA-(7'-TRIFLUOROMETHYLQUINOLIN-4'-YL)METHANOL AND NAPHTHYRIDIN-4-YL)-ALPHA-(PIPERIDIN-2'-YL)METHANOL, Australian Journal of Chemistry, 46(11), 1993, pp. 1695-1703
Citations number
18
Categorie Soggetti
Chemistry
Journal title
Australian Journal of Chemistry → ACNP
ISSN journal
00049425
Volume
46
Issue
11
Year of publication
1993
Pages
1695 - 1703
Database
ISI
SICI code
0004-9425(1993)46:11<1695:PA.SAT>2.0.ZU;2-Z
Abstract
The synthesis of the mefloquine analogue )-alpha-(7'-trifluoromethylqu inolin-4'-yl)methanol (1) from 4-bromo-7-trifluoromethylquinoline and N-(hex-5-enyl)phthalimide through thylquinolin-4''-yl)oxiran-2'-yl]but yl}phthalimide 1''-oxide is reported. naphthyridin-4-yl)-alpha-(piperi din-2'-yl)methanol (2) was prepared by similar procedures. In tests ag ainst the K-1 isolate of Plasmodium falciparum, compound (1) proved th e more active (IC50 99 nM).