MIXED CONNECTIVE-TISSUE DISEASE PRESENTING MYASTHENIA-GRAVIS

We herein describe a 41-year-old female patient with an association of myasthenia gravis (MG) with anti-acetylcholine receptor (AcR) antibod y, mixed connective tissue disease (MCTD) and Sjogren's syndrome (SjS) . We reviewed the reported association of MG and MCTD, systemic lupus erythematosus, progressive systemic sclerosis, polymyositis and dermat omyositis, and SjS. Since me could find only two patients who fulfille d the diagnostic criteria for MCTD in the previous literature, we conc luded that the association of MG and MCTD is rare. We also discuss the coexistence of SjS as one of the underlying pathological conditions f or the association of MG and various connective tissue diseases includ ing MCTD.