PURPOSE: To determine sonographic features associated with locally rec
urrent or residual tumor. MATERIALS AND METHODS: Twenty-three transrec
tal ultrasound (TRUS) studies were performed in 21 patients with suspe
cted recurrent prostatic carcinoma after prostatectomy. The original p
rospective TRUS reports were reviewed, followed by blinded review, and
the findings were compared with biopsy results. RESULTS: A discrete p
erianastomotic mass was identified prospectively in eight (73%) of 11
patients with positive biopsy results and in two (17%) of 12 with nega
tive results; no mass was identified in the remaining patients. At pre
liminary retrospective review, the echogenic retroanastomotic fat plan
e was not intact in 10 (91%) of 11 patients with positive biopsy resul
ts and in two (17%) of 12 with negative results; it was intact in the
remaining patients. CONCLUSION: Sonographic visualization of a mass in
the prostate bed or loss of integrity of the retroanastomotic fat pla
ne is strongly correlated with finding recurrent or residual tumor in
this location. TRUS in evaluation of the source of postoperative eleva
tion of prostate-specific antigen levels warrants further investigatio
n.