WALKER-WARBURG SYNDROME - A REPORT OF 3 CASES

Walker-Warburg syndrome is a congenital malformation syndrome of unkno wn etiology which is characterized by fatal neurological lesions. It w as first described by Walker in 1942 as involving agyria, hydrocephalu s and eye malformations. Its etiology has been discussed in all of the articles on the subject in the literature, but the majority of the au thors describe it as an autosomal recessive syndrome. Ultrasonography plays a key role in detecting a cephalic anomaly by prenatal diagnosis as in our 2 cases. The aim of this article is to report 3 new cases o f Walker-Warburg syndrome in two families. Knowledge of this syndrome emphasizes both the need for ultrasonographic observation and genetic counselling for families at risk.