A COMPARATIVE-STUDY OF CYCLOSPORINE AND ITS DERIVATIVE SDZ IMM-125 INCANINE RENAL-ALLOGRAFTS

Authors
WATSON CJE METCALFE SM COLLIER DGS CALNE RY
Citation
Cje. Watson et al., A COMPARATIVE-STUDY OF CYCLOSPORINE AND ITS DERIVATIVE SDZ IMM-125 INCANINE RENAL-ALLOGRAFTS, Transplantation, 56(5), 1993, pp. 1248-1250
Citations number
4
Categorie Soggetti
Immunology,Surgery
Journal title
Transplantation → ACNP
ISSN journal
00411337
Volume
56
Issue
5
Year of publication
1993
Pages
1248 - 1250
Database
ISI
SICI code
0041-1337(1993)56:5<1248:ACOCAI>2.0.ZU;2-0
Abstract
The immunosuppressive efficacy of CsA and its derivative SDZ IMM-125 w as compared in highly mismatched mongrel dogs in receipt of renal allo grafts. At an equal dose of 15 mg/kg/day and in the same drug vehicle, SDZ IMM-125 was not superior to CsA in prolonging allograft survival. Whole blood levels of SDZ IMM-125 were lower than those achieved for CsA. No specific drug-related side effects were noticed in this model.