G. Hempel et al., DETERMINATION OF PACLITAXEL IN BIOLOGICAL-FLUIDS BY MICELLAR ELECTROKINETIC CHROMATOGRAPHY, Journal of chromatography, 745(1-2), 1996, pp. 173-179
Citations number
13
Categorie Soggetti
Chemistry Analytical","Biochemical Research Methods
A method has been developed for the determination of paclitaxel (Taxol
) in plasma and urine using capillary electrophoresis with sodium dode
cyl sulfate as additive in the run buffer. The samples are extracted a
nd preconcentrated with tert.-butyl methyl ether. Taxotere has been us
ed as the internal standard. The limit of detection for paclitaxel is
20 ng/ml. In comparison to high-performance liquid chromatography, the
capillary electrophoresis method is simple and needs less organic sol
vents.