CHOROIDO-CEREBRAL CALCIFICATION SYNDROME WITH RETARDATION

We present a sibship with a rare syndrome characterized by mental reta rdation, dense calcification of the lateral ventricular choroid plexus , and increased CSF protein. Neurophysiologic studies yielded nonspeci fic results, and endocrine studies, including parathormone levels, wer e normal. Simultaneous measurements of CSF and serum calcium, magnesiu m, and other electrolytes were normal, but the CSF/serum ratio of phos phate was low, suggesting a possible role in the pathogenesis of this syndrome.