CHARACTERIZATION OF 2 MARKER CHROMOSOMES IN A PATIENT WITH ACUTE NONLYMPHOCYTIC LEUKEMIA BY 2-COLOR FLUORESCENCE IN-SITU HYBRIDIZATION

Authors
TANIWAKI M SPEICHER MR LENGAUER C JAUCH A POPP S CREMER T
Citation
M. Taniwaki et al., CHARACTERIZATION OF 2 MARKER CHROMOSOMES IN A PATIENT WITH ACUTE NONLYMPHOCYTIC LEUKEMIA BY 2-COLOR FLUORESCENCE IN-SITU HYBRIDIZATION, Cancer genetics and cytogenetics, 70(2), 1993, pp. 99-102
Citations number
21
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
70
Issue
2
Year of publication
1993
Pages
99 - 102
Database
ISI
SICI code
0165-4608(1993)70:2<99:CO2MCI>2.0.ZU;2-H
Abstract
A patient with acute nonlymphocytic leukemia (ANLL), M5b according to French-American-British (FAB) classification, showed monosomy 16, an e xtra 1p-, and a 21q+. These derivative chromosomes could not be define d by GTG-banding. For better characterization, we performed two-color fluorescence in situ hybridization (FISH) experiments applying DNA lib raries from sorted human chromosomes, chromosome-specific repetitive p robes, and a band-specific YAC-clone. With these FISH studies the kary otype could be characterized as 46,XY, + der(1)t(1;21)(p11;?), -16,der (21)t(16;21)(p11.1;q22).