DEVELOPMENT OF 2ND-GENERATION MONOCLONAL-ANTIBODIES RECOGNIZING LEWIS(Y B) ANTIGEN BY ANTIIDIOTYPIC IMMUNIZATION/

Authors
DURRANT LG SINGHAL A JACOBS E PRICE MR
Citation
Lg. Durrant et al., DEVELOPMENT OF 2ND-GENERATION MONOCLONAL-ANTIBODIES RECOGNIZING LEWIS(Y B) ANTIGEN BY ANTIIDIOTYPIC IMMUNIZATION/, Hybridoma, 12(6), 1993, pp. 647-660
Citations number
20
Categorie Soggetti
Immunology
Journal title
Hybridoma → ACNP
ISSN journal
0272457X
Volume
12
Issue
6
Year of publication
1993
Pages
647 - 660
Database
ISI
SICI code
0272-457X(1993)12:6<647:DO2MRL>2.0.ZU;2-K
Abstract
Five new monoclonal antibodies (Mabs) recognising the Lewis(y/b) hapte n of the IgG isotype have been produced following immunisation with ra t anti-idiotypic antiserum to C14, an IgM Lewis(y/b) hapten Mab and bo osting with C14gp200 antigen. They have the same fine specificity as t he original Mab binding to a cell surface and secreted antigen prefere ntially expressed by colorectal tumour cells.