PULSATILE GONADOTROPIN-RELEASING-HORMONE STIMULATION AFTER MEDIUM-TERM PITUITARY SUPPRESSION IN POLYCYSTIC-OVARY-SYNDROME

Ovulation induction in the polycystic ovary syndrome with pulsatile go nadotrophin releasing hormone (GnRH) in the recovery phase after treat ment with a GnRH agonist (GnRHa) during 6-8 weeks has been reported to improve ovulation and pregnancy rates and to normalize follicular pha se luteinizing hormone (LH) levels. We studied the results of stimulat ion with pulsatile GnRH after a shorter 'medium-term' period of 3 week s of treatment with a GnRHa by comparing a cycle without GnRHa pre-tre atment with a cycle with GnRHa (post-GnRHa) pre-treatment in 12 patien ts. We could prove no significant clinical improvement in post-GnRHa c ycles. Ovulation rates were similar. However, in the post-GnRHa cycles , two ongoing pregnancies were observed versus one spontaneous abortio n in the cycles without GnRHa pre-treatment. This observation might be explained by the fact that follicular phase LH levels in post-GnRHa c ycles were significantly decreased.