CONCURRENT ACUTE EXERCISE ALTERS CENTRAL AND PERIPHERAL RESPONSES TO PHYSOSTIGMINE

This study reports the modulatory effects of physostigamine (Phy) and concurrent acute exercise on the time course of cholinesterase (ChE) a ctivity, the rate of decarbamylation (K(d)), and half-time of recovery of ChE in red blood cells (RBC) and various tissues of rats. Acute ex ercise equivalent to 80% VO2max (maximal oxygen consumption) transient ly increased the RBC ChE activity, whereas Phy decreased ChE activity in RBC and various tissues. Physostigmine along with concurrent acute exercise increased the K(d) in RBC, brain, and heart by 56.4%, 66.7%, and 139%, respectively, compared to Phy alone. The K(d) in diaphragm a nd muscle decreased to 14.1% and 56.2%, respectively, compared to Phy alone. The variation in K(d) might be due to the effect of concurrent acute exercise on the redistribution of Phy in various tissues of rat as a result of changes in blood flow.