Sn. Dube et al., CONCURRENT ACUTE EXERCISE ALTERS CENTRAL AND PERIPHERAL RESPONSES TO PHYSOSTIGMINE, Pharmacology, biochemistry and behavior, 46(4), 1993, pp. 827-834
This study reports the modulatory effects of physostigamine (Phy) and
concurrent acute exercise on the time course of cholinesterase (ChE) a
ctivity, the rate of decarbamylation (K(d)), and half-time of recovery
of ChE in red blood cells (RBC) and various tissues of rats. Acute ex
ercise equivalent to 80% VO2max (maximal oxygen consumption) transient
ly increased the RBC ChE activity, whereas Phy decreased ChE activity
in RBC and various tissues. Physostigmine along with concurrent acute
exercise increased the K(d) in RBC, brain, and heart by 56.4%, 66.7%,
and 139%, respectively, compared to Phy alone. The K(d) in diaphragm a
nd muscle decreased to 14.1% and 56.2%, respectively, compared to Phy
alone. The variation in K(d) might be due to the effect of concurrent
acute exercise on the redistribution of Phy in various tissues of rat
as a result of changes in blood flow.