Si. Deutsch et J. Mastropaolo, DISCRIMINATIVE STIMULUS PROPERTIES OF MIDAZOLAM ARE SHARED BY A GABA-RECEPTOR POSITIVE STEROID, Pharmacology, biochemistry and behavior, 46(4), 1993, pp. 963-965
3-Alpha-5-alpha-tetrahydrodeoxycorticosterone (alloTHDOC) is a 3-alpha
ring A-reduced metabolite of deoxycorticosterone that has been shown
to act via nongenomic mechanisms to modulate the GABA(A) receptor comp
lex allosterically in vitro. Moreover, there are behavioral data consi
stent with the anxiolytic actions of GABA-receptor positive steroids.
The drug discrimination paradigm was used in rats to demonstrate that
effects of alloTHDOC are mediated by the GABA(A) receptor complex in t
he intact animal. In rats trained to discriminate 1.8 mg/kg of midazol
am from saline, alloTHDOC substituted for the training stimulus.