PRODUCTION OF PARATHYROID HORMONE-RELATED PROTEIN BY CULTURED HUMAN MYELOMA CELLS

Authors
SUZUKI A TAKAHASHI T OKUNO Y TSUYUOKA R SASAKI Y FUKUMOTO M KATAKAMI H KITA K SHIBUYA T
Citation
A. Suzuki et al., PRODUCTION OF PARATHYROID HORMONE-RELATED PROTEIN BY CULTURED HUMAN MYELOMA CELLS, American journal of hematology, 45(1), 1994, pp. 88-90
Citations number
10
Categorie Soggetti
Hematology
Journal title
American journal of hematology → ACNP
ISSN journal
03618609
Volume
45
Issue
1
Year of publication
1994
Pages
88 - 90
Database
ISI
SICI code
0361-8609(1994)45:1<88:POPHPB>2.0.ZU;2-U
Abstract
We examined whether or not parathyroid hormone-related protein (PTH-rP ) is produced in cultured human myeloma cells. PTH-rP protein was dete cted in the cell extract of one (U266) of 6 myeloma cell lines examine d by radioimmunoassay. Also we demonstrated the expression of PTH-rP m RNA in all of the 6 lines. These findings indicate that PTH-rP may be one of the factors responsible for the bone destruction or hypercalcem ia in multiple myeloma. (C) 1994 Wiley-Liss, Inc.