A RECEPTOR FOR INTERLEUKIN-10 IS RELATED TO INTERFERON RECEPTORS

Authors
HO ASY LIU Y KHAN TA HSU DH BAZAN JF MOORE KW
Citation
Asy. Ho et al., A RECEPTOR FOR INTERLEUKIN-10 IS RELATED TO INTERFERON RECEPTORS, Proceedings of the National Academy of Sciences of the United Statesof America, 90(23), 1993, pp. 11267-11271
Citations number
42
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Proceedings of the National Academy of Sciences of the United Statesof America → ACNP
ISSN journal
00278424
Volume
90
Issue
23
Year of publication
1993
Pages
11267 - 11271
Database
ISI
SICI code
0027-8424(1993)90:23<11267:ARFIIR>2.0.ZU;2-1
Abstract
We isolated cDNAs encoding a mouse interleukin 10 receptor (mIL-10R) f rom mouse mast cell and macrophage cell lines. The two cDNAs are subst antially identical and express an almost-equal-to 110-kDa polypeptide in COS7 cells, which binds mIL-10 specifically. A mouse pro-B-cell lin e (Ba/F3) expressing transfected recombinant mIL-10R binds IL-10 with high affinity (almost-equal-to 70 pM) and proliferates in response to mIL-10. mIL-10R is structurally related to interferon receptors (IFNRs ). Since IL-10 inhibits macrophage activation by IFN-gamma, a possible implication of this relationship is interaction of IL-10R and IFN-gam maR or their signaling pathways.