M. Mukai et al., 3 CASES OF ANTI-SCL-70 (TOPOISOMERASE-1) ANTIBODY ASSOCIATED WITH CENTRAL-NERVOUS-SYSTEM LUPUS WITHOUT RENAL DISORDER, Journal of rheumatology, 20(9), 1993, pp. 1594-1597
We describe 3 cases of systemic lupus erythematosus (SLE) associated w
ith anti-Scl-70 antibody. Common symptoms were central nervous system
disorder, discoid rash, lymphadenopathy, and no renal disorder. Two of
3 cases showed some symptoms of scleroderma but could not be diagnose
d as such. Although further followup is required to determine if scler
oderma develops, these unique symptoms might be a subtype of SLE or a
lupus-like syndrome characterized by symptoms and anti-Scl-70 antibody
.