CYTOSKELETON-ASSOCIATED ANTIGENS FROM AFRICAN TRYPANOSOMES ARE RECOGNIZED BY SELF-REACTIVE ANTIBODIES OF UNINFECTED MICE

Authors
MULLER N IMBODEN M DETMER E MANSFIELD JM SEEBECK T
Citation
N. Muller et al., CYTOSKELETON-ASSOCIATED ANTIGENS FROM AFRICAN TRYPANOSOMES ARE RECOGNIZED BY SELF-REACTIVE ANTIBODIES OF UNINFECTED MICE, Parasitology, 107, 1993, pp. 411-417
Citations number
14
Categorie Soggetti
Parasitiology
Journal title
Parasitology → ACNP
ISSN journal
00311820
Volume
107
Year of publication
1993
Part
4
Pages
411 - 417
Database
ISI
SICI code
0031-1820(1993)107:<411:CAFATA>2.0.ZU;2-1
Abstract
Serum from uninfected mice of different strains, as well as from germ- free animals, contains antibodies which react specifically with at lea st two trypanosomal proteins, I/6 and MARP1. These antibody population s are highly specific for the respective proteins, are of similar affi nity as hyperimmune antibodies, and consist of IgM as well as IgG isot ypes. Hyperimmune antibody raised against the cross-reacting trypanoso mal protein I/6 detects a 60 kDa protein in mouse 3T6 cells, which is a component of the fibroblast cytoskeleton.