Fo. Bryant et al., PROPERTIES AND COST-EFFECTIVE METHOD FOR PRODUCTION OF THE ANTITUMOR AGENT DUCLAUXIN FROM SPORULATING PENICILLIUM-HERQUEI, Journal of pharmaceutical sciences, 82(12), 1993, pp. 1214-1217
Duclauxin, an antitumor agent, was isolated from sporulating Penicilli
um herquei (ATCC 34665) grown on a medium of peanut hulls supplemented
with potato starch solution (termed ''Gostar''). The medium was inocu
lated with a sporulating subculture of P. herquei established on a 2%
potato starch slurry supplemented with mineral salts. The P. herquei g
rew as well on Gostar as on an enriched medium. Duclauxin was isolated
in crystalline form from Gostar-grown P. herquei. Comparison of costs
of duclauxin obtained from inexpensive Gostar versus costly enriched
media indicated that Gostar reduces production expenses. Duclauxin was
not effective as an antibiotic against certain species of gram-positi
ve and gram-negative bacteria, fungi, and viruses, but a concentration
-dependent inhibition of wheat coleoptile growth was observed. Duclaux
in was characterized by melting point, optical rotation, IR and NMR sp
ectroscopy, MS and X-ray diffraction.