NECESSARY CONDITIONS FOR THE PI-ELECTRON DELOCALIZATION IN ENAMINO-TYPE MUSCLE-RELAXANTS

Two necessary conditions have been proposed for the pi-electron deloca lization across four bonds in bis-quaternary bromides of enamino spiro -ketal-type compounds. Dynamic NMR data analysis of these compounds su ggests that pi-electron delocalization takes place if the first atom i s nitrogen and the fourth atom is either nitrogen or oxygen [i.e., N+= C-C=N (or O)]. The second condition is that the end atoms of the four- bond system should not be therminal group.