SYNTHESIS OF CIS-2-PENTENE-CONTAINING NUCLEOSIDE ANALOGS AND THEIR TRIPHOSPHATES

Authors
MITSNER BI KOCHETKOVA MV FILIPPOV DV TSYTOVICH AV DYATKINA NB
Citation
Bi. Mitsner et al., SYNTHESIS OF CIS-2-PENTENE-CONTAINING NUCLEOSIDE ANALOGS AND THEIR TRIPHOSPHATES, Molecular biology, 27(1), 1993, pp. 105-111
Citations number
7
Categorie Soggetti
Biology
Journal title
Molecular biology → ACNP
ISSN journal
00268933
Volume
27
Issue
1
Year of publication
1993
Part
2
Pages
105 - 111
Database
ISI
SICI code
0026-8933(1993)27:1<105:SOCNAA>2.0.ZU;2-9
Abstract
Acyclic analogs of thymidine, cytidine, and adenosine containing cis-5 -hydroxy-2-pentene instead of the ribose ring were synthesized by cond ensation of 1-bromo-cis-5-acetoxy-2-pentene with nucleic bases. Their triphosphates were also synthesized to assess the ability of the hydro xypentene nucleoside derivatives to act as termination substrates in D NA synthesis by DNA polymerases.