Methods are discussed which combine surface, interface and thin-film m
easurements with the analysis of limited spatial domains. The progress
which is now occurring rapidly is illustrated. The methods treated ar
e selected from the beam-imaging methods, based on electron, ion, x-ra
y beam and laser interaction with the solid sample. Two examples are g
iven concerned on one side with the ion microprobe analysis of micro s
tructures in electronic devices and on the other side with the charact
erization of surface-modified asbestos by electron energy loss spectro
metry and electron spectroscopic imaging.