Findings on the efficacy of nutritional supplements used by athletes a
re reviewed. Many athletes have turned away from anabolic steroids and
toward nutritional supplements in the hope of gaining a competitive e
dge without threatening their health. Athletes may require slightly mo
re protein than sedentary people do to maintain positive nitrogen bala
nce, but it is dubious whether extra dietary protein will help someone
to achieve athletic goals. Purified amino acids have become a popular
if expensive form of protein supplementation; there is no scientific
evidence, however, to support their use. Excessive protein supplementa
tion can lead to dehydration, gout, liver and kidney damage, calcium l
oss, and gastrointestinal effects. Supplementation with vitamins and m
inerals in excess of recommended daily allowances appears to have no e
ffect on muscle mass or athletic performance. Other substances touted
as having ergogenic properties are carnitine, cobamamide, growth hormo
ne releasers, octacosanol, and ginseng; again, there is no reliable sc
ientific evidence to support claims that products containing these com
pounds have ergogenic potential, and heavy supplementation may lead to
adverse effects. Nutritional supplements are promoted through unsubst
antiated claims by magazine advertisements, health food stores, coache
s, and other sources. The FDA considers nutritional supplements to be
foodstuffs, not drugs, and therefore has not required that they be pro
ved safe and effective. Dosage guidelines are inadequate, and quality
control is poor. The FDA has begun to revise regulations governing lab
eling and health claims for these products. There is little if any evi
dence that nutritional supplements have ergogenic effects in athletes
consuming a balanced diet, and some products have the potential for ha
rm.