PHARMACOKINETICS OF THIAMIN AFTER ORAL-ADMINISTRATION OF THIAMIN TETRAHYDROFURFURYL DISULFIDE TO HUMANS

We performed a pharmacokinetic analysis of the blood thiamin profile a fter oral administration of thiamin tetrahydrofurfuryl disulfide (TTFD ) to healthy adults. To distinguish between thiamin derived from TTFD ingestion and that from previous dietary intake, the baseline thiamin level was subtracted from the apparent blood vitamin levels measured a fter administration. Following administration of 100 mg of TTFD, the p eak blood thiamin level was almost 10 times the baseline level and the blood thiamin profile could be simulated by a two-compartment model t o obtain reasonable pharmacokinetic parameters. When the blood thiamin profile for a 10-mg dose of TTFD was estimated using scaled-down phar macokinetic parameters derived at the 100-mg dose level, a reasonable fit for the raw data obtained at 10-mg dose was obtained. Therefore, t he parameters derived from the data at a dose of 100 mg appeared to be reliable. Since even 180 mg of TTFD is completely absorbed and the ab sorption ratio is independent of the dose, it can be concluded that ga strointestinal absorption of TTFD is good within the dose range.