N. Kitamori et Y. Itokawa, PHARMACOKINETICS OF THIAMIN AFTER ORAL-ADMINISTRATION OF THIAMIN TETRAHYDROFURFURYL DISULFIDE TO HUMANS, Journal of nutritional science and vitaminology, 39(5), 1993, pp. 465-472
We performed a pharmacokinetic analysis of the blood thiamin profile a
fter oral administration of thiamin tetrahydrofurfuryl disulfide (TTFD
) to healthy adults. To distinguish between thiamin derived from TTFD
ingestion and that from previous dietary intake, the baseline thiamin
level was subtracted from the apparent blood vitamin levels measured a
fter administration. Following administration of 100 mg of TTFD, the p
eak blood thiamin level was almost 10 times the baseline level and the
blood thiamin profile could be simulated by a two-compartment model t
o obtain reasonable pharmacokinetic parameters. When the blood thiamin
profile for a 10-mg dose of TTFD was estimated using scaled-down phar
macokinetic parameters derived at the 100-mg dose level, a reasonable
fit for the raw data obtained at 10-mg dose was obtained. Therefore, t
he parameters derived from the data at a dose of 100 mg appeared to be
reliable. Since even 180 mg of TTFD is completely absorbed and the ab
sorption ratio is independent of the dose, it can be concluded that ga
strointestinal absorption of TTFD is good within the dose range.