WOLFRAM-SYNDROME - A CLINICAL-STUDY OF 2 CASES

Two unrelated patients with two different images of Wolfram (or 'DIDMO AD') syndrome are presented: a 19-year old woman suffering from all th e important features of this syndrome, and a 38-year old man showing t wo major characteristics but several minor abnormalities. This syndrom e should be considered in young diabetic patients with unexplained vis ual loss or with polyuria and polydipsia in the presence of adequate b lood sugar control. An early diagnosis is important to prevent unneces sary diagnostic investigations.