COMPARATIVE MUTAGENIC ACTIVITY OF 7 DERIV ATIVES OF BIPHENYL AND FLUORENONE

Comparative mutagenic activity of 7 derivatives of byphenyl and fluore none, 4,4'-dinitrobyphenyl-2,2'-dicarboxic acid; 4,4',6,6'-tetranitrob yphenyl-2,2'-dicarboxicamid; 2-nitrofluorenon-5-carbosic acid; 2,7-din itrofluorenon-5-carboxic acid; 2,7-dinitrofluorenon-5-carbonic amid; 2 -nitrofluorenon-5,7-dicarboxic acid; 2,4-dinitrofluorenon-5,7-dicarbox ic acid was studied. The highest activity was demonstrated for 2,7-DNF -5-KA and 2,7-DNF-5,7-DK which induced frameshift mutations in the tes ter strains Salmonella typhymurium TA1537, TA97, TA1538, TA98. High mu tagenicity of these compounds is correlated with the position of nitro groups and the effects of carboxic and carboxiamid groups.