ON THE PLANNING OF SAMPLES FOR LINKAGE AN ALYSIS - INCOMPLETE PENETRANCE

Dependence of the minimal size of a pedigree sample providing the give n quality of a linkage decision on the genotype penetrance of the loca lized gene is considered. The two ways of the sample informativity inc rease are discussed and their effects are estimated. These ways are: t he adequate choice of a marker gene and certain complicatrion of a ped igree structure. It is shown for the latter that the effect can be ach ieved only for certain phenotypic characteristrics of the additional p edigree members.