EFFECTS OF ALPRAZOLAM ON A MODEL OF HUMAN ABSENCES - RHYTHMIC METRAZOL ACTIVITY IN RATS

Authors
KUBOVA H MARES P
Citation
H. Kubova et P. Mares, EFFECTS OF ALPRAZOLAM ON A MODEL OF HUMAN ABSENCES - RHYTHMIC METRAZOL ACTIVITY IN RATS, Physiological Research, 42(5), 1993, pp. 361-364
Citations number
18
Categorie Soggetti
Physiology
Journal title
Physiological Research → ACNP
ISSN journal
08628408
Volume
42
Issue
5
Year of publication
1993
Pages
361 - 364
Database
ISI
SICI code
0862-8408(1993)42:5<361:EOAOAM>2.0.ZU;2-W
Abstract
Two doses of alprazolam (0.1 and 0.5 mg.kg(-1)) were tested against a model of human absences - rhythmic EEG activity elicited by low doses of pentylenetetrazol (35 mg.kg(-1)) - in 10 unrestrained rats with imp lanted cortical electrodes. Alprazolam delayed the onset of epileptic EEG activity, decreased the number of rhythmic episodes and shortened the total duration of rhythmic activity in a dose-dependent manner. Th e average duration of episodes of rhythmic activity remained unchanged ; other benzodiazepines studied previously were able to influence this measure.