IN-VITRO AND IN-VIVO EXPERIMENTAL SUSCEPTIBILITY OF MYCOBACTERIUM-MARINUM TO AUGMENTIN

The effect of augmentin alone and in combination with various beta-lac tam antibiotics was studied against a pathogenic Mycobacterium, M. mar inum. The in vitro studies did not reveal any additional advantage ove r that found with augmentin alone and this antibiotic seemed considera bly inhibitory to M. marinum at < 1 mu g/ml concentration. In vivo, th e effects of augmentin on experimentally produced lesions in the mouse foot pads (MFPs) showed a significant regression of the lesions, whic h was compatible with an early disappearance of M. marinum from the MF P, in contrast with those of the untreated, control animals.