A. Chakrabarti et al., IN-VITRO AND IN-VIVO EXPERIMENTAL SUSCEPTIBILITY OF MYCOBACTERIUM-MARINUM TO AUGMENTIN, INDIAN JOURNAL OF MEDICAL RESEARCH, 104, 1996, pp. 281-283
The effect of augmentin alone and in combination with various beta-lac
tam antibiotics was studied against a pathogenic Mycobacterium, M. mar
inum. The in vitro studies did not reveal any additional advantage ove
r that found with augmentin alone and this antibiotic seemed considera
bly inhibitory to M. marinum at < 1 mu g/ml concentration. In vivo, th
e effects of augmentin on experimentally produced lesions in the mouse
foot pads (MFPs) showed a significant regression of the lesions, whic
h was compatible with an early disappearance of M. marinum from the MF
P, in contrast with those of the untreated, control animals.