ENANTIOMERIC SEPARATION BY CYCLODEXTRIN-MODIFIED MICELLAR ELECTROKINETIC CHROMATOGRAPHY USING BILE-SALT

Authors
LIN M WU NA BARKER GE SUN P HUIE CW HARTWICK RA
Citation
M. Lin et al., ENANTIOMERIC SEPARATION BY CYCLODEXTRIN-MODIFIED MICELLAR ELECTROKINETIC CHROMATOGRAPHY USING BILE-SALT, Journal of liquid chromatography, 16(17), 1993, pp. 3667-3674
Citations number
17
Categorie Soggetti
Chemistry Analytical
Journal title
Journal of liquid chromatography → ACNP
ISSN journal
01483919
Volume
16
Issue
17
Year of publication
1993
Pages
3667 - 3674
Database
ISI
SICI code
0148-3919(1993)16:17<3667:ESBCME>2.0.ZU;2-9
Abstract
A method for enantiomeric separation by cyclodextrin-modified micellar electrokinetic chromatography (MEKC) with bile salt micelles is descr ibed. The enantiomeric resolution was achieved with a mixed sodium tau rodeoxycholate (TDC)-beta-cyclodextrin (CD) solution (pH 7-9) utilizin g a bare capillary. In sodium dodecyl sulfate (SDS)-CD solutions, simi lar result were not obtained. The effect of varying concentrations of TCD and beta-CD and pH on the selectivity and resolution were also bri efly investigated.