BIPOLAR AFFECTIVE-DISORDER PRIOR TO THE ONSET OF MULTIPLE-SCLEROSIS

The frequent association of affective disorder and multiple sclerosis raises important aetiological and clinical considerations. Reported he re are seven patients who presented with symptoms of multiple sclerosi s and who had a preceding history of bipolar affective disorder. The h ypothesis that bipolar illness may be the initial manifestation of mul tiple sclerosis is discussed with reference to relevant clinical and e pidemiological research on the topic.