PROTECTIVE EFFECT OF DS-4574 ON GASTRIC-MUCOSAL INJURY-INDUCED BY ACIDIFIED ETHANOL IN RATS

We compared the protective effect of DS-4574, a peptidoleukotriene rec eptor antagonist with mast cell stabilizing action, on rat gastric muc osal injury induced by acidified ethanol to that of LYI71883, a select ive peptidoleukotriene receptor antagonist. Oral treatment with DS-457 4 (1-10 mg/kg) or LY171883 (100 and 300 mg/kg) markedly suppressed thi s mucosal necrosis. Moreover, DS-4574 (10 mg/kg) significantly inhibit ed both mucosal edema and degranulation of mucosal mast cells. LY17188 3 (300 mg/kg) protected only from mucosal edema. but not degranulation of mucosal mast cells. These results suggest that DS-4574 possesses p rotective actions against gastric injury including the reduction of de granulation of mucosal mast cells, which are different from those of L Y171883.